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Evening Primrose Oil: Benefits, Side Effects and Safety


Scientific name: Oenothera biennis Also called: evening primrose oil, EPO

Evening primrose is a plant with yellow flowers. Its seeds provide an oil rich in omega-6 fatty acids. People use this oil as a supplement for many health goals.

What is evening primrose oil?

This plant grows in North and South America, Europe, and Asia. Its flowers open at sunset. The oil from its seeds contains a fatty acid called gamma-linolenic acid (GLA).

Native Americans once used the plant to treat skin issues and wounds. Today, people take it for eczema, joint pain, and symptoms of menopause.

What are the benefits of evening primrose oil?

There is not enough evidence to support using this oil for any health condition. Studies show it does not help with eczema symptoms. It is also not better than a fake pill (a placebo) for breast pain.

Some people use it to help start labor during pregnancy. Research on this has had mixed results. We do not have enough proof that it helps with PMS or joint pain.

What are the side effects of evening primrose oil?

Most adults tolerate this oil well. The most common side effects are stomach issues. These include belly pain, feeling sick, or diarrhea.

We know little about its safety in children. The long-term safety of using it to start labor is also not clear.

How much should you take?

There is no standard dose for evening primrose oil. Talk to your doctor to see if it is right for you. They can help you decide on a safe amount.

Does it have drug interactions?

NCCIH warns that some herbs and medicines interact in harmful ways. It does not name specific medicines for this oil. You should tell your doctor about all products you use.

Who should not take evening primrose oil?

Talk to your doctor if you are pregnant or breastfeeding. While the oil may be safe, the evidence is not certain. Your doctor can help you make an informed choice.

Is it regulated by the FDA?

The FDA does not approve dietary supplements before they are sold. Rules for supplements are less strict than for drugs. The FDA can only act if a safety concern arises.

Common questions about evening primrose oil

Does it help with eczema?
No. Research shows that taking it by mouth does not help with eczema symptoms.
Can I take it while pregnant?
The evidence is not clear. Talk to your doctor before using it to start labor or for any other reason.
Is it safe for children?
We do not know much about the safety of this oil for children.
Does it cause stomach pain?
Yes, some people have belly pain, nausea, or diarrhea after taking it.
This page is for education only. It is not medical advice, and it is not a recommendation to take evening primrose oil. Natural Medical Solutions Wellness Center does not diagnose, treat, or cure. Supplements can affect how your medicines work. Talk with your doctor and your pharmacist before you start, stop, or change any supplement, and keep working with the providers you already see.

Where this information comes from

Written from NCCIH, a public-domain resource from the U.S. National Institutes of Health. Information retrieved 2026-08-21.

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