Natural Medical SolutionsGrape seed extract comes from the seeds of wine grapes. It is sold as a supplement for many health uses. People also use it on their skin to help wounds heal.
What is grape seed extract?
This extract is made from the seeds of wine grapes. It contains natural compounds called proanthocyanidins. These compounds may have effects that help manage health issues.
You can find it in products taken by mouth or used on the skin. It is often sold as a dietary supplement.
What are the benefits of grape seed extract?
Many people use this extract for heart health. Research shows it may help with certain cholesterol levels. It may lower low-density lipoprotein (LDL) cholesterol and triglycerides.
It does not seem to change total cholesterol or high-density lipoprotein (HDL) levels. Some studies also show it may lower the bottom number of a blood pressure reading.
These results are not certain. The studies were small and used different types of products.
What does the research say?
Research on other uses is very limited. Scientists have looked at using it on the skin for wounds. There is not enough evidence to know if it works.
Laboratory studies suggest it might help prevent tooth decay when used in a mouth rinse. However, there is not enough research in people to prove this.
What are the side effects of grape seed extract?
Grape seed extract is generally well tolerated. This applies when it is taken by mouth or used on the skin. There is little information about its safety during pregnancy or while breastfeeding.
Is grape seed extract regulated?
Dietary supplements are not approved by the FDA before they are sold. The rules for making them are less strict than for drugs. Manufacturers must ensure their own products are safe before they sell them.
How much should you take?
There is no standard dose for grape seed extract. Research studies have used different amounts and lengths of time. Talk to your doctor to decide what is right for you.
Does it interact with medications?
NCCIH warns that some herbs and medicines interact in harmful ways. It does not name specific medicines for grape seed extract. Always tell your doctor about any supplements you use.
Who should not take grape seed extract?
Talk to your health care provider before using this extract if you take any medicine. Little is known about its safety for women who are pregnant or breastfeeding. Always check with your doctor before starting a new supplement.
Common questions about grape seed extract
Does grape seed extract lower blood pressure?
Is it safe to use on my skin?
Does the FDA approve grape seed extract?
Related on this site
Where this information comes from
Written from NCCIH, a public-domain resource from the U.S. National Institutes of Health. Information retrieved 2026-08-21.
Ready to heal naturally?
Start your personalized naturopathic, functional & holistic care plan in Roswell, GA, proudly serving Alpharetta, Atlanta & the north metro.
